The ECHA  Committee for Risk Assessment (RAC) has been assessing TiO2 under the CLP regulation. Today, 9 June,  ECHA published a press release that 'Titanium dioxide proposed to be classified as suspected of causing cancer when inhaled'.  RAC concluded that the available scientific evidence meets the criteria in the CLP Regulation to classify titanium dioxide as a substance suspected of causing cancer through the inhalation route. The opinion will be formally adopted by RAC by written procedure or at the September meeting.

The RAC classification is based solely on the hazardous properties of the substance. Therefore, it does not take into account the likelihood of exposure to the substance and therefore does not address exposure or any risk of TiO2. 

The dossier is covering TiO2 as a substance and is not specific for nanomaterials. However, the outcome of the RAC decision can have far reaching implications for classifications of other partially soluble low-toxicity particles.

The discussion is based on the CLH Report prepared by France as the Rapporteur Member State. The Rapporteur proposed that TiO2 to be classified as Carc. 1B-H350i, carcinogenicity. However this is based on a very controversial overload study in rats, and many stakeholder have concerns on classifying a substance based on this information. These concerns have been expressed during the public consultation of the CLH Report .  The final decision on classification will be taken by the European Commission.